Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies

Author:

Horvath Steve12,Oshima Junko34,Martin George M.3,Lu Ake T.1,Quach Austin1,Cohen Howard5,Felton Sarah6,Matsuyama Mieko7,Lowe Donna8,Kabacik Sylwia8,Wilson James G.9,Reiner Alex P.10,Maierhofer Anna11,Flunkert Julia11,Aviv Abraham12,Hou Lifang13,Baccarelli Andrea A.14,Li Yun15,Stewart James D.16,Whitsel Eric A.1617,Ferrucci Luigi18,Matsuyama Shigemi719,Raj Kenneth8

Affiliation:

1. Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA

2. Department of Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA 90095, USA

3. Department of Pathology, University of Washington, Seattle, WA 98195, USA

4. Department of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan

5. Elizabeth House, Warlingham, Surrey CR6 9LF, United Kingdom

6. Department of Dermatology, Oxford University Hospitals NHS Foundation Trust, Oxford OX3 7LJ, United Kingdom

7. Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA

8. Radiation Effects Department, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Didcot, Oxfordshire OX11 0RQ, United Kingdom

9. Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA

10. Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA

11. Institute of Human Genetics, Julius Maximilians University, Würzburg, Germany

12. Center of Development and Aging, New Jersey Medical School, Rutgers State University of New Jersey, Newark, NJ 07103, USA

13. Center for Population Epigenetics, Robert H. Lurie Comprehensive Cancer Center and Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA

14. Laboratory of Environmental Epigenetics, Departments of Environmental Health Sciences and Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USA

15. Departments of Genetics, Biostatistics, Computer Science, University of North Carolina, Chapel Hill, NC 27599, USA

16. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA

17. Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC 27516, USA

18. Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA

19. Department of Pathology and Pharmacology, Case Comprehensive Centre, Case Western Reserve University, Cleveland, OH 44106, USA

Publisher

Impact Journals, LLC

Subject

Cell Biology,Aging

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