Centenarians as super-controls to assess the biological relevance of genetic risk factors for common age-related diseases: A proof of principle on type 2 diabetes

Author:

Garagnani Paolo123,Giuliani Cristina4,Pirazzini Chiara12,Olivieri Fabiola56,Bacalini Maria Giulia12,Ostan Rita12,Mari Daniela7,Passarino Giuseppe8,Monti Daniela9,Bonfigli Anna Rita10,Boemi Massimo10,Ceriello Antonio1112,Genovese Stefano13,Sevini Federica12,Luiselli Donata4,Tieri Paolo14,Capri Miriam12,Salvioli Stefano12,Vijg Jan1516,Suh Yousin15171618,Delledonne Massimo1920,Testa Roberto21,Franceschi Claudio1

Affiliation:

1. DIMES - Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, 40126 Italy

2. C.I.G. Interdepartmental Center “L. Galvani”, University of Bologna, Bologna, Italy

3. CRBA - Applied Biomedical Research Center, S. Orsola-Malpighi Polyclinic, Bologna, 40138 Italy

4. Department of Biological, Geological and Environmental Sciences, Laboratory of Molecular Anthropology & Centre for Genome Biology, University of Bologna, Bologna 40126, Italy

5. Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy

6. Center of Clinical Pathology and Innovative Therapy, Italian National Research Center on Aging INRCA-IRCCS, Ancona, Italy

7. Geriatric Unit IRCCS Ca' Granda Foundation Maggiore Policlinico Hospital Hospital and Department of Clinical Sciences and Community Health, University of Milano, Italy

8. Department of Cell Biology, University of Calabria, Rende, Italy

9. Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy

10. Metabolic Diseases and Diabetology Unit, IRCCS-INRCA, Ancona, Italy

11. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain

12. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain

13. Department of Cardiovascular and Metabolic Diseases, IRCCS Gruppo Multimedica Sesto San Giovanni (MI), Italy

14. IAC-CNR Istituto per le Applicazioni del Calcolo, Consiglio Nazionale delle Ricerche, Rome, Italy

15. Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA

16. Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA

17. Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA

18. Institute of Aging Research, Guangdong Medical College, Dongguan 523808, China

19. Personal Genomics SRL, Strada le Grazie 15, 37133 Verona - Italy

20. Functional Genomics Center, Dept. of Biotechnologies, University of Verona, Strada le Grazie 15, 37133 Verona - Italy

21. Experimental Models in Clinical Pathology, IRCCS-INRCA, Ancona, Italy

Publisher

Impact Journals, LLC

Subject

Cell Biology,Aging

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