1. Department of Immunology, School of Basic Medical Sciences, Binzhou Medical University, Yantai 264003, Shandong, P.R. China
2. Equal contribution
3. Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, P.R. China
4. Binzhou Medical University, Yantai 264003, Shandong, P.R. China
5. Anti-aging Research Institution, Binzhou Medical University, Yantai 264003, Shandong, P.R.China
6. Department of Stomatology, Affiliated Hospital of Binzhou Medical College, Binzhou 256603, Shandong, P.R. China
7. Division of Infectious Diseases and Global Health, School of Medicine, University of California at San Diego, La Jolla, CA 92037, USA
8. School of Agriculture, Ludong University, Yantai 264025, Shandong, P.R.China