I ՏԻՊԻ ՇԱՔԱՐԱՅԻՆ ԴԻԱԲԵՏՈՎ ՀԻՎԱՆԴՆԵՐԻ ԳԵՆԵՏԻԿԱԿԱՆ ԿԱՅՈՒՆՈՒԹՅԱՆ ՀԵՏԱԶՈՏՈՒՄԸ ՄԻԿՐՈԿՈՐԻԶԱՅԻՆ ԹԵՍՏԻ ՄԻՋՈՑՈՎ

Abstract

The level of micronuclei and other nuclear anomalies in the exfoliative cells of the oral mucosa of diabetes mellitus type I patients and healthy subjects was investigated using the micronucleus test. Correlation analysis was performed based on the results obtained in the exfoliative cells of patients with type I diabetes of the Armenian population with the micronucleus test, their laboratory and anthropometric data, and an extremely small p-value was obtained, which shows very strong evidence of the obtained correlational relationship. Therefore, the research conducted allows us to conclude that type I diabetes has a statistically significant effect on the genetic instability of the organism of patients with diabetes, at the same time having a statistically high cytotoxic and genotoxic effect.