High Sensitivity of Mobile Phone Microscopy Screening for Schistosoma haematobium in Azaguié, Côte d’Ivoire

Author:

Coulibaly Jean T.12,Silue Kigbafori D.12,Armstrong Maxim3,Díaz de León Derby María3,D’Ambrosio Michael V.3,Fletcher Daniel A.345,Keiser Jennifer67,Fisher Karla8,Andrews Jason R.9,Bogoch Isaac I.810

Affiliation:

1. Unité de Formation et de Recherche Biosciences, Université Félix Houphouët-Boigny, Abidjan, Côte d’Ivoire;

2. Centre Suisse de Recherches Scientifiques en Côte d’Ivoire, Abidjan, Côte d’Ivoire;

3. Department of Bioengineering, University of California, Berkeley, Berkeley, California;

4. Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, Berkeley, California;

5. Chan Zuckerberg Biohub, San Francisco, California;

6. Swiss Tropical and Public Health Institute, Allschwil, Switzerland;

7. University of Basel, Basel, Switzerland;

8. Divisions of General Internal Medicine and Infectious Diseases, Toronto General Hospital, University Health Network, Toronto, Canada;

9. Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California;

10. Department of Medicine, University of Toronto, Toronto, Canada

Abstract

ABSTRACT. Schistosomiasis infections continue to impact African settings disproportionately, and there is an urgent need for novel tools to evaluate infection control and elimination strategies at the community level. Mobile phone microscopes are portable and semiautomated devices with multiple applications for screening neglected tropical diseases. In a community-based schistosomiasis screening program in Azaguié, Côte d’Ivoire, mobile phone microscopy demonstrated a sensitivity of 85.7% (95% CI: 69.7–95.2%) and specificity of 93.3% (95% CI: 87.7–96.9%) for Schistosoma haematobium identification compared with conventional light microscopy, and 95% sensitivity (95% CI: 74.1–99.8%) with egg concentrations of five or more per 10 mL of urine. Mobile phone microscopy is a promising tool for schistosomiasis control and elimination efforts.

Publisher

American Society of Tropical Medicine and Hygiene

Subject

Virology,Infectious Diseases,Parasitology

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