Case Report: A Case of Bone Marrow Necrosis and Hyperinflammation in a 10-Year-Old Boy after Plasmodium falciparum Infection-Reference-Cited by-同舟云学术

Case Report: A Case of Bone Marrow Necrosis and Hyperinflammation in a 10-Year-Old Boy after Plasmodium falciparum Infection

Published:2023-09-06 Issue:3 Volume:109 Page:611-615
ISSN:0002-9637
Container-title:The American Journal of Tropical Medicine and Hygiene
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Author:

Hui Caitlyn¹²,Bosch Alessandra²³,Mwizerwa Oscar²⁴,McColl Jeanine²⁴,Corbeil Antoine⁵,Malcolmson Caroline²³,Levy Deborah M.²⁴,Bismilla Zia²⁶,Morris Shaun K.¹²

Affiliation:

1. Division of Pediatric Infectious Diseases, The Hospital for Sick Children, Toronto, Canada;

2. Department of Pediatrics, Temerty Faculty of Medicine, The University of Toronto, Toronto, Canada;

3. The Division of Pediatric Hematology/Oncology, The Hospital for Sick Children, Toronto, Canada;

4. Division of Pediatric Rheumatology, The Hospital for Sick Children, Toronto, Canada;

5. Microbiology and Laboratory Science, Public Health Ontario, Toronto, Canada;

6. Division of Pediatric Medicine, The Hospital for Sick Children, Toronto, Canada

Abstract

ABSTRACT. A 10-year-old boy with sickle cell disease (SCD) type SC presented with fever and abdominal pain after travel to Ghana and was diagnosed with Plasmodium falciparum infection. Despite adequate antimalarial treatment, he developed evidence of hyperinflammation with marked elevated ferritin, C-reactive protein, and triglycerides and subsequent bone marrow necrosis, characterized by elevated nucleated red blood cells and significant bone pain. This case report highlights the possible association between malaria and bone marrow necrosis in patients with SCD. Important considerations in treatment and workup of patients presenting with malaria and hyperinflammation are discussed.

Publisher

American Society of Tropical Medicine and Hygiene

Subject

Virology,Infectious Diseases,Parasitology

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