Case Report: Cutaneous Leishmaniasis in a Rheumatoid Arthritis Patient Receiving Methotrexate-Reference-Cited by-同舟云学术

Case Report: Cutaneous Leishmaniasis in a Rheumatoid Arthritis Patient Receiving Methotrexate

Published:2022-10-12 Issue:4 Volume:107 Page:785-788
ISSN:0002-9637
Container-title:The American Journal of Tropical Medicine and Hygiene
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Author:

Amato Valdir Sabbaga¹²,Maia de Souza Regina¹,Moyses Franco Lucas Augusto¹²,Ruedas Martins Roberta Cristina¹,Maia da Silva Camila Alves¹,Emori Christini Takemi²,Celeste Beatriz Julieta³,Castanheira Gabriel Victor¹²,Tuon Felipe Francisco⁴

Affiliation:

1. Universidade de São Paulo, Instituto de Medicina Tropical de São Paulo, Laboratório de Parasitologia, São Paulo, São Paulo, Brazil;

2. Universidade de São Paulo, Faculdade de Medicina, Departamento de Moléstias Infecciosas e Parasitárias, São Paulo, São Paulo, Brazil;

3. Universidade de São Paulo, Instituto de Medicina Tropical de São Paulo, Laboratório de Soroepidemiologia, São Paulo, São Paulo, Brazil;

4. Laboratory of Emerging Infectious Diseases, Pontificia Universidade Católica do Paraná, Curitiba, Paraná, Brazil

Abstract

ABSTRACT. The immunosuppressive effect of methotrexate has rarely been associated with reactivation of cutaneous leishmaniasis. Here we present a case of a cutaneous leishmaniasis patient with atypical clinical symptoms without splenomegaly but with cutaneous manifestations after treatment of rheumatoid arthritis with methotrexate and blood recovery of the parasite. Next-generation sequencing was used to identify Leishmania infantum chagasi in the patient’s blood sample.

Publisher

American Society of Tropical Medicine and Hygiene

Subject

Virology,Infectious Diseases,Parasitology

Link

https://www.ajtmh.org/downloadpdf/journals/tpmd/107/4/article-p785.xml

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