Case Report: Local Treatment of a Leishmania tropica Infection in a Syrian Child with a Novel Filmogenic Preparation of Pharmaceutical Sodium Chlorite (LeiProtect®)-Reference-Cited by-同舟云学术

Case Report: Local Treatment of a Leishmania tropica Infection in a Syrian Child with a Novel Filmogenic Preparation of Pharmaceutical Sodium Chlorite (LeiProtect®)

Published:2022-01-10 Issue: Volume: Page:
ISSN:0002-9637
Container-title:The American Journal of Tropical Medicine and Hygiene
language:
Short-container-title:

Author:

Debus Dirk¹,Genç Semra²,Kurz Philipp²,Holzer Martin³,Bauer Kurt³,Heimke-Brinck Ralph⁴,Baier Martin⁴,Sebald Heidi⁵,Debus Andrea⁵,Bogdan Christian⁵⁶,Stahl Kurt-Wilhelm⁷

Affiliation:

1. 1Department of Dermatology, Paracelsus Medizinische Privatuniversität, Klinikum Nürnberg, Prof.-Ernst-Nathan-Straße 1, Germany;

2. 2Institute for Inorganic and Analytical Chemistry and Freiburg Material Research Center (FMF), Albert-Ludwigs-University Freiburg, Albertstraße 21, Freiburg, Germany;

3. 3Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology and Biopharmacy, Albert-Ludwigs-Universität, Hermann-Herder-Straße 9, Freiburg, Germany;

4. 4Pharmacy Department, Universitätsklinikum Erlangen, Palmsanlage 3, Erlangen, Germany;

5. 5Mikrobiologisches Institut – Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Wasserturmstraße 3/5, Erlangen, Germany;

6. 6Medical Immunology Campus Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Schlossplatz 1, Erlangen, Germany;

7. 7Waisenmedizin e. V. Promoting Access to Care with Essential Medicine (PACEM), Non-Profit Non-Governmental Organization, Günterstalstraße 60, Freiburg, Germany

Abstract

Cutaneous leishmaniasis (CL) frequently entails chronic skin lesions that heal only slowly. Until now, the available therapeutic options are very limited. Here, we present a case of a 5½-year-old Syrian refugee with two progressive lower-leg skin ulcers caused by Leishmania tropica. The patient received topical treatment with LeiProtect®, a newly developed, hydroxypropylcellulose-based, filmogenic gel containing nontoxic concentrations of pharmaceutical sodium chlorite. The skin lesions completely healed within 8 weeks and did not relapse during 1 year of follow-up, underlining the efficacy of this novel local therapy of CL.

Publisher

American Society of Tropical Medicine and Hygiene

Subject

Virology,Infectious Diseases,Parasitology

Link

https://www.ajtmh.org/downloadpdf/journals/tpmd/aop/article-10.4269-ajtmh.21-0962/article-10.4269-ajtmh.21-0962.xml

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Successful treatment of complex cutaneous leishmaniasis (L. tropica) in a 3‐year‐old Syrian boy with miltefosine;JDDG: Journal der Deutschen Dermatologischen Gesellschaft;2024-06-27

2. Leishmania infections and Leishmania species in central Europe;WIEN TIERARZTL MONAT;2023