Case Report: Calcified Cerebral Toxoplasmosis Associated with Perilesional Edema in People Living with HIV/AIDS: Case Series of a Presentation Mimicking Neurocysticercosis

Author:

Vidal José E.123,Rivero René L. M.4,dos Santos Sigrid de Sousa5,Guedes Bruno F.6,Gomes Hélio R.67,Penalva de Oliveira Augusto C.1,Garcia Hector H.89

Affiliation:

1. 1Departamento de Neurologia, Instituto de Infectologia Emílio Ribas, São Paulo, Brazil;

2. 2Divisão de Moléstias Infecciosas, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil;

3. 3LIM 49, Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil;

4. 4Setor de Radiologia, Divisão de Apoio ao Diagnóstico e Terapêutica, Instituto de Infectologia Emílio Ribas, São Paulo, Brazil;

5. 5Departamento de Medicina, Universidade Federal de São Carlos, São Carlos, Brazil;

6. 6Departmento de Neurologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil;

7. 7LIM 14, Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil;

8. 8Centro de Salud Global, Universidad Peruana Cayetano Herédia, Lima, Peru;

9. 9Unidad de Cisticercosis, Instituto de Ciencias Neurológicas, Lima, Peru

Abstract

ABSTRACT. Perilesional edema, associated or not with neurological manifestations, is a well-characterized finding in cases of calcified neurocysticercosis. There are no previous reports of HIV-related calcified toxoplasmosis that mimics this presentation of neurocysticercosis. We report on five patients, four of them with new-onset neurological manifestations, who showed brain calcifications associated with perilesional edema. All cases had a history of HIV-related toxoplasmosis and current virological and immunological control of HIV infection. Similar to neurocysticercosis, brain calcified toxoplasmosis may cause perilesional edema and symptoms in people living with HIV/AIDS.

Publisher

American Society of Tropical Medicine and Hygiene

Subject

Virology,Infectious Diseases,Parasitology

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