Case Report: Therapeutic Threshold for Rifampicin-Resistant Tuberculosis in a Patient from Maputo, Mozambique-Reference-Cited by-同舟云学术

Case Report: Therapeutic Threshold for Rifampicin-Resistant Tuberculosis in a Patient from Maputo, Mozambique

Published:2021-04-07 Issue:4 Volume:104 Page:1317-1320
ISSN:0002-9637
Container-title:The American Journal of Tropical Medicine and Hygiene
language:
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Author:

Gonzaga Lorena D. M.¹,Gils Tinne²,Decroo Tom²³,Jacobs Bart K. M.²,Lynen Lutgarde²

Affiliation:

1. 1Centro de Saude Primeiro de Maio, Maputo, Mozambique;

2. 2Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium;

3. 3Research Foundation Flanders, Brussels, Belgium

Abstract

ABSTRACTWe present a case of a patient in Mozambique, who initiated treatment for rifampicin-resistant tuberculosis (RR-TB) without proof of resistance. For this patient, we estimated the probability of RR-TB using likelihood ratios of clinical arguments. The probability of RR-TB in Mozambique, positive HIV status, and treatment failure after a first treatment and after retreatment were included as confirming arguments, and a rapid molecular test showing rifampicin susceptibility as excluding argument. The therapeutic threshold to start treatment for RR-TB is unknown, but probably lower than 47% and should be calculated to guide clinical decisions.

Publisher

American Society of Tropical Medicine and Hygiene

Subject

Virology,Infectious Diseases,Parasitology

Link

https://www.ajtmh.org/downloadpdf/journals/tpmd/104/4/article-p1317.xml

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