Safety and Immunogenicity of an AS03B-Adjuvanted Inactivated Tetravalent Dengue Virus Vaccine Administered on Varying Schedules to Healthy U.S. Adults: A Phase 1/2 Randomized Study

Author:

Lin Leyi1,Lyke Kirsten E.2,Koren Michael1,Jarman Richard G.1,Eckels Kenneth H.1,Lepine Edith3,McArthur Monica A.2,Currier Jeffrey R.1,Friberg Heather1,Moris Philippe4,Keiser Paul B.1,De La Barrera Rafael1,Vaughn David W.3,Paris Robert M.3,Thomas Stephen J.1,Schmidt Alexander C.3

Affiliation:

1. Walter Reed Army Institute of Research, Silver Spring, Maryland;

2. Center for Vaccine Development and Global Health (CVD), University of Maryland, Baltimore, Maryland;

3. GSK, Rockville, Maryland;

4. GSK, Rixensart, Belgium

Publisher

American Society of Tropical Medicine and Hygiene

Subject

Virology,Infectious Diseases,Parasitology

Reference22 articles.

1. Dengue vaccine: WHO position paper–September 2018;Wkly Epidemiol Rec,2018

2. The global burden of dengue: an analysis from the Global Burden of Disease Study 2013;Stanaway;Lancet Infect Dis,2016

3. Prospective cohort study with active surveillance for fever in four dengue endemic countries in Latin America;Dayan;Am J Trop Med Hyg,2015

4. Historical perspectives on flavivirus research;Holbrook;Viruses,2017

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