Case Report: Severe Plasmodium vivax Malaria after Splenectomy

Author:

Kambuaya Noy Norman1,Rini Hasrini1,Shanti Putu Ayu Indra2,Alexander King2,Candrawati Freis1,Prayoga Pak1,Leonardo Leo1,Margayani Dewi Sri1,Yayang Bagus Tesa Gina1,Kenangalem Enny12,Buffet Pierre A.3,Anstey Nicholas M.4,Poespoprodjo Jeanne Rini125,Kho Steven14

Affiliation:

1. Timika Malaria Research Facility, Papuan Health and Community Development Foundation, Timika, Papua, Indonesia;

2. Rumah Sakit Umum Daerah Kabupaten Mimika, Timika, Papua, Indonesia;

3. Institut Pasteur, University of Paris, Paris, France;

4. Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia;

5. Department of Pediatrics, Gadjah Mada University, Yogyakarta, Indonesia

Abstract

ABSTRACT. Severe malaria after splenectomy has been reported with infections with Plasmodium falciparum, Plasmodium knowlesi, and Plasmodium malariae, but is less well-characterized with Plasmodium vivax. We describe a case of severe P. vivax malaria with hypotension, prostration, and acute kidney injury occurring 2 months after splenectomy in Papua, Indonesia. The patient was treated successfully with intravenous artesunate.

Publisher

American Society of Tropical Medicine and Hygiene

Subject

Virology,Infectious Diseases,Parasitology

Reference23 articles.

1. Central role of the spleen in malaria parasite clearance;Chotivanich,2002

2. The human spleen in malaria: filter or shelter?;Henry,2020

3. Hidden biomass of intact malaria parasites in the human spleen;Kho,2021

4. Evaluation of splenic accumulation and colocalization of immature reticulocytes and Plasmodium vivax in asymptomatic malaria: a prospective human splenectomy study;Kho,2021

5. Hazard of overwhelming infection after splenectomy in childhood;Eraklis,1967

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