Assessment of the Otolith-Autonomic Response Using Spectral Analysis of the R-R Interval and Blood Pressure

Abstract

The effects of otolith stimulation on systolic blood pressure (SBP) and R-R interval fluctuations were investigated in 12 healthy subjects and 5 patients with loss of labyrinthine function. The vestibular otolith organs were stimulated by centrifugal forces, the constant rotation of a chair fixed outside of the rotation axis on the horizontal plane. The chair was fixed along the direction of centrifugal force (eccentric rotation (ECR)) or along the tangent line (eccentric lateral rotation (ECLR)). The ECR stimulates both the utricular and saccular maculae, whereas the ECLR stimulates only the utricular maculae. Spectral analysis showed that in the healthy subjects, low-frequency SBP increased significantly during ECR but not during ECLR. There was no significant increase in low-frequency SBP in patients with labyrinthine loss. In the R-R interval analysis, however, the low- and high-frequency components did not change significantly in the healthy subjects during ECR. Our findings indicate that stimulation of the otolith maculae, especially the saccular organs, predominantly produces augmentation of the α-sympathetic activities rather than cardiac sympathovagal outflow to the heart.