Laryngeal Compartmentalization after Radiation Therapy in a Canine Model-Reference-Cited by-同舟云学术

Laryngeal Compartmentalization after Radiation Therapy in a Canine Model

Published:2001-10 Issue:4 Volume:125 Page:385-392
ISSN:0194-5998
Container-title:Otolaryngology–Head and Neck Surgery
language:en
Short-container-title:Otolaryngol Head Neck Surg

Author:

Yu Larry¹²³,Iii Charles Syms¹⁴³,Dietz Wolfgang¹⁵³

Affiliation:

1. Las Vegas, Nevada, San Antonio, Texas, and Dayton, Ohio

2. From the Ear Nose and Throat Consultants of Nevada

3. Dayton.

4. Las Vegas; the Ear Medical Group

5. San Antonio; and private practice

Abstract

OBJECTIVE: We set out to study the effects of radiation therapy on laryngeal tissue barriers in a canine model as described by Welsh. STUDY DESIGN: India ink was injected into 1 vocal fold on irradiated and nonirradiated canine larynges. RESULTS: The india ink dye spread more prominently into the supraglottis of the irradiated specimens by submucosal lymphatics. Larger dye volumes simulating larger tumor bulk spread to the contralateral larynx in irradiated specimens. CONCLUSION: Conservation laryngeal surgery for laryngeal carcinoma is a popular method of treatment. Some surgeons advocate partial laryngectomy for radiation failures; in other instances, it is the primary modality of treatment. These findings suggest a cautious approach when planning conservative laryngeal surgery after radiation therapy failures of glottic carcinoma.

Publisher

SAGE Publications

Subject

Otorhinolaryngology,Surgery

Link

http://journals.sagepub.com/doi/pdf/10.1067/mhn.2001.117716

Reference18 articles.

1. LXXXI Further Studies upon the Submucosal Compartments and Lymphatics of the Larynx by the Injection of Dyes and Radioisotopes