Mechanism of Electro-Oxidation of Metamizole Using Ciclic Voltammetry at a Glassy Carbon Electrode

Abstract

Cyclic Voltammetry at glassy carbon electrode was applied to study the electro-oxidation of Metamizole, a pro-drug largely used in many countries as analgesic which the therapeutic properties are attributed to its hydrolyzed form. Metamizole presents three oxidation processes in aqueous (Britton Robinson Buffer) and DMF media. The first process was characterized as reversible in the last medium. The differentiation between the process associated with the Metamizole and its respective hydrolyzed form the MAA, was investigated and allowed the proposition of a mechanism for the Metamizole electro-oxidation.