Perspective—The Feasibility of Continuous Protein Monitoring in Interstitial Fluid

Author:

Young ThomasORCID,Clark VincentORCID,Arroyo-Currás NetzahualcóyotlORCID,Heikenfeld JasonORCID

Abstract

Real-time continuous monitoring of proteins in-vivo holds great potential for personalized medical applications. Unfortunately, a prominent knowledge gap exists in the fundamental biology regarding protein transfer and correlation between interstitial fluid and blood. Additionally, technological sensing will require affinity-based platforms that cannot be robustly protected in-vivo and will therefore be challenged in sensitivity, longevity, and fouling over multi-day to week timelines. Here we use electrochemical aptamer sensors as a model system to discuss further research necessary to achieve continuous protein sensing.

Funder

Air Force Office of Scientific Research

National Institute of Biomedical Imaging and Bioengineering

University of Cincinnati Venture Lab

Office of Naval Research

National Science Foundation

Publisher

The Electrochemical Society

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