Performance Analysis of Electrochemical Detection Platform for DNA Hybridization Using TGN-Based Nanobiosensor

Abstract

Trilayer graphene nanoribbon (TGN) has great potential in related biomedical applications such as drug and gene delivery and deoxyribonucleic acid (DNA) sensing. The performance of a biosensor based on a liquid gate TGN field effect transistor (Lg-TGNFET) to different DNA cancentrations and adsorption effect on the sensing parameters are analytically investigated in this research. Also, the energy band structure, density of states, carrier concentration, electrical conductance and caused electrical response on TGN as a detection element are studied considering the spin–orbit coupling effect, in which significant current change of the TGN-based biosensor is observed after exposure to DNA different values. DNA concentration as a function of gate voltage is assumed and sensing factor is defined. The results of this research confirm that the current of the biosensor is decreased and Vg-min is obviously left-shifted by increasing value of DNA concentration, suggesting that DNA molecules n-dopes the TGN film. In order to verify the accuracy of the TGN-based biosensor, it is compared with recent analytical and experimental reports on DNA biosensors. The proposed biosensor with high specificity and sensitivity exposes higher current compared to that of monolayer graphene counterpart for analogous ambient conditions.