Abstract
Prucalopride succinate (PCP) was determined by potentiometry using an ion-selective electrode to obtain the most optimum ion-selective electrode. A screening study was carried out to determine the best membrane components, in which a PCP selective electrode was investigated with dioctyl phthalate as a plasticizer in a polymeric polyvinyl chloride polymeric matrix. Sensors were fabricated using phosphotungstic acid as an exchanger and β-cyclodextrin as an ionophore. Then, an optimization process was carried out, which involved the detection of significant factors affecting membrane response variables followed by the establishment of Box Behnken design in which levels of the selected factors, namely, percent of matrix, a ratio of plasticizer: polyvinyl chloride, and Log of soaking concentration were carefully selected (three levels for each factor). The optimized membrane was examined by measuring the slope, LOQ, linearity of PCP, and response time as response variables. Linear responses of PCP within the concentration ranges of 9.99 × 10−8−3.39 × 10−5 mol l−1 were obtained, and a slope of 61.591 ± 1.112 was observed. The selectivity coefficients of the developed sensors indicated excellent selectivity for PCP. The proposed sensor displayed useful analytical characteristics for the sensitive and selective determination of PCP.
Publisher
The Electrochemical Society