Multimode Detection Platform Based on 3D Integrated Sensor for Fast On-Site Assay of Methylprednisolone in Its Pharmaceutical Formulation and Surface Water Samples

Abstract

A portable electrochemical platform that detects methylprednisolone in two switchable modes has been developed. Both two selected modes, square wave voltammetry and stochastic, provide qualitative and quantitative analysis of the analyte. Under optimal conditions, the platform recorded the following linear concentration ranges, between 1.00 and 1.00 × 103 μmol l‒1 when using the square wave voltammetry mode, and a much wider range between 1.00 × 10‒9 and 1.00 × 104 μmol l‒1 when using the stochastic mode. The limits of quantification recorded were: 1.00 fmol l−1 for the stochastic mode, and 1.00 μmol l−1 for the square wave voltammetry mode. The developed platform was successfully applied for the assay of methylprednisolone in real samples (pharmaceutical dosage form and surface water), when recoveries higher than 90.00% were obtained.