Abstract
Due to high sensitivity and temporal resolution, surface plasmon resonance microscope (SPRM) has been widely used in biological analysis. In this review, we briefly introduced the principle and setup of SPRM. Applications in label-free biological analysis are also indicated, including fast detection to single cells, exosomes, viruses, and molecules, as well as their dynamic behaviors. The limitations of SPRM are also depicted. The methods to improve the focus drift and low spatial resolution are illustrated. Two newly-developed microscopy techniques based on SPRM, i.e. plasmonic scattering microscope and electrochemical impedance microscope, are also described. Finally, a summary of SPRM technique and a bright future outlook is presented.
Funder
Beijing Natural Science Foundation
Scientific Research Equipment Project of Chinese Academy of Sciences
Publisher
The Electrochemical Society
Subject
Materials Chemistry,Electrochemistry,Surfaces, Coatings and Films,Condensed Matter Physics,Renewable Energy, Sustainability and the Environment,Electronic, Optical and Magnetic Materials
Cited by
3 articles.
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