Abstract
Echinacoside(ECH) is a phenylethanoid glycoside compound with various pharmacological activity in Chinese medicine. The development of convenient, efficient and sensitive analysis methods for ECH in complex samples in vitro and in vivo has considerable application value. In this study, honeycomb graphene oxide (H-GO) with highly conductivity and nanoscale defect-like structure was successfully prepared by combustion method. It was used as a modified material for flexible electrode (ITO-PET), and then activated in alkaline solution to construct a nanomaterial modified electrode (aH-GO/ITO-PET). The imprinted sensor (MIP/aH-GO/ITO-PET) was further constructed by simple electropolymerization and elution. Under optimized conditions, the sensor achieves sensitive detection of ECH in a wide linear range of 0.1 ∼ 100 μM, with a detection limit as low as 1.6 nM (S/N = 3), and has good repeatability, stability and anti-interference. It has been successfully used for the direct detection of ECH in Cistanche deserticola Ma wine and rat plasma.
Funder
National Natural Science Foundation of China
National Key Research and Development Program of China
People's Livelihood Special Project from Technical Innovation Guide Plan of Gansu Province
Talent Innovation and Entrepreneurship Project of Lanzhou
Key Research and Development Project of GanSu Province
Key Talent Project of Organization Department of Gansu Provincial Party Committee
Central Government Guiding Local Science and Technology Development Fund Project
Publisher
The Electrochemical Society
Subject
Materials Chemistry,Electrochemistry,Surfaces, Coatings and Films,Condensed Matter Physics,Renewable Energy, Sustainability and the Environment,Electronic, Optical and Magnetic Materials