Abstract
4-aminophenol (4-AP), a typical secondary product from pharmaceuticals preparation, can lead to dangerous collateral effects in drugs. It’s crucial to develop suitable methods for fast and accurate determination of 4-AP. Herein, a novel and fast electrochemical method based on flower-like Ag-Au nanocomposites modified electrode has been developed for accurate determination of 4-AP. The flower-like Ag-Au nanocomposites were synthesized via a seed-mediated growth route utilizing L-dopa as reduction agent and assembled by 2-dimension nanosheets. The electrochemical oxidation of 4-AP on Ag-Au nanocomposites modified electrode was studied by using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The modified electrode exhibited excellent electrocatalytic activity toward 4-AP. Under the optimized conditions, the sensor displayed high sensitivity for the detection of 4-AP in the linear range from 0.1 to 100 μM with detection limit of 36 nM (S/N = 3). The fabricated electrode showed high selectivity, good reproducibility, and long-term stability to 4-AP detection. Furthermore, the developed electrochemical sensor showed no interference for simultaneous detection of 4-AP and acetaminophen. It was also demonstrated that the sensor could be applied for the analysis of pharmaceutical products.
Funder
National Natural Science Foundation of China
Publisher
The Electrochemical Society
Subject
Materials Chemistry,Electrochemistry,Surfaces, Coatings and Films,Condensed Matter Physics,Renewable Energy, Sustainability and the Environment,Electronic, Optical and Magnetic Materials
Cited by
28 articles.
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