Phthalocyanine-Based Two-Dimensional Conductive Metal–Organic Framework as Electrochemical Sensor for Highly Sensitive Detection of Nifedipine

Abstract

A conductive two-dimensional, phthalocyanine metal–organic framework material (CoPc-Cu MOF) was successfully modified onto a glassy carbon electrode (GCE) to construct an electrochemical sensor for the high-sensitivity detection of nifedipine (NIF). The 2D MOF was obtained by complexing (2,3,9,10,16,17,23,24-octahydroxyphthalocyaninato) cobalt(II) ([OH]8PcCo) with copper(II) ions (denoted as CoPc-Cu MOF). Under optimal conditions, the CoPc-Cu MOF/GCE sensor showed a wide linear range (0.01−92.55 μM) and a low detection limit (6.0 nM) for the determination of NIF. Moreover, the electrochemical sensor exhibited high repeatability, stability, and selectivity. The electrochemical sensing platform was applied to the real determination of NIF in tablets and showed satisfactory results.