Review—Aptasensors: Cutting-Edge Technologies for Bisphenol A Detection as an Endocrine Disruptor

Abstract

Recently, research has been focused on detection of bisphenol A (BPA), a prominent endocrine disruptor (EDC) because of major health concerns. It is mostly employed as raw material to produce harmful environmental pollutants such polycarbonate plastics, thermal papers, and epoxy resins. BPA is renowned EDC that mimics oestrogen hormone produced by humans and disrupts both endocrine and reproductive systems. Although many analytical methods have been used to detect BPA biosensors, but using aptamers, as a bioreceptor has shown to be fairly promising in this respect because of its inexpensiveness, speed, high sensitivity, and specificity and portable benefits. Quantum dots, metal associated oxide nanocomposites, metal-organic framework, polymer nanocomposites, carboneous nanomaterials and molecularly imprinted polymers were all proposed as aptamer-based sensors for the sensitive screening of BPA. This review summarises advancements done in aptasensors area since 2011 for determination of BPA in food products, water samples and human body fluids using different transducer, including electrochemical, optical and other techniques. In addition, this article delves into the challenges and potential opportunities associated with aptasensors specifically tailored for BPA recognition. It serves as valuable resource for researchers and scientists offering insights that can guide future studies and advancements in the new aptasensors development for BPA detection.