<p>The present study aims to investigate the human thermal stress with respect to the synoptic scale circulation over the metropolitan city of Athens in Greece. The Universal Thermal Climate Index (UTCI) was applied in order to assess the levels of thermal stress employing three-hour meteorological data for four stations of the urban complex for a ten-year period (2006-2015). The patterns of the synoptic atmospheric circulation were classified in eight distinct categories based on a clustering scheme. The obtained results in summer reveal low UTCI values on days that are associated with a cyclonic pattern or a cold advection from the northwest or north. On the contrary, the days with an anticyclonic pattern show high UTCI values. During winter, low UTCI values are observed on days that are associated with a pure cyclonic pattern, a prevailing northern flow and a strong cold air advection from the northwest or north. During nighttime, high UTCI values are noted on days with south-westerly flow. However, this is not observed during daytime and especially around midday. The analysis also shows that the position of the station affects the levels of thermal stress for the same synoptic category.</p>