Progress of Chinese Medicine Monomers and Combinations in Intervening Gefitinib Resistance in Non-small Cell Lung Cancer-Reference-Cited by-同舟云学术

Progress of Chinese Medicine Monomers and Combinations in Intervening Gefitinib Resistance in Non-small Cell Lung Cancer

Published:2024-06-30 Issue:6 Volume:6 Page:259-263
ISSN:2006-2745
Container-title:Journal of Contemporary Medical Practice
language:
Short-container-title:JCMP

Author:

Gao Kongque,Li Renting

Abstract

Lung cancer is one of the common malignant tumors in clinic, among which the incidence of NSCLC accounts for about 85%, and the effect of the EGFR-TKI drug represented by gefitinib in the treatment of NSCLC is remarkable in clinic, but the acquired drug resistance is However, acquired drug resistance is one of the important reasons affecting the efficacy of gefitinib. In recent years, many studies have found that traditional Chinese medicine (TCM) can improve the sensitivity of lung cancer cells to gefitinib, and this paper focuses on the mechanism of TCM monomers and combinations in reversing the resistance to gefitinib from the aspects of increasing the concentration of intracellular drugs, inducing apoptosis of drug-resistant cells and inhibiting the signaling pathway of NSCLC, with the aim of providing a reference to find safe and effective reversal of drug resistance agents.

Publisher

Century Science Publishing Co

Reference36 articles.

1. He S, Xia C, Li H, et al. Cancer profiles in China and comparisons with the USA: a comprehensive analysis in the incidence, mortality, survival, staging, and attribution to risk factors[J]. Science China Life Sciences, 2023.

2. Relli V, Trerotola M, Guerra E, et al. Abandoning the Notion of Non-Small Cell Lung Cancer[J]. Trends in Molecular Medicine, 2019, 25(7): 585-594.

3. AI Xinyi, HOU Xuefeng, FENG Nianping. Reversal of drug resistance in human non-small cell lung cancer by combining comedicine and gefitinib and its mechanism [J]. Chinese Journal of Traditional Chinese Medicine, 2024, 49(1): 175-184.

4. CHEN Zhi, YU Jiandong, TANG Chaoyuan, et al. Effects of elemene injection on the intracellular transport kinetics of gefitinib in PC-9/GR cells[J]. Chinese Patent Medicine, 2018, 40(2): 284-290.

5. FANG Xupeng, FANG Dan, DANG Haibin, et al. Effects of Lung Yan Ning Fang combined with Gefitinib on the proliferation of lung adenocarcinoma H1975 cells in vitro[J]. Shanghai Journal of Traditional Chinese Medicine, 2022, 56(8): 79-83.