Research Progress of Traditional Chinese Medicine Based on TGF-β/Smad Signal Pathway in Preventing and Treating Myocardial Fibrosis in Heart Failure

Abstract

Heart failure is the terminal stage of cardiovascular disease, and its pathological mechanism is ventricular remodeling. Therefore, the fundamental of preventing and treating heart failure is to inhibit ventricular remodeling. The important link of ventricular remodeling is myocardial fibrosis. It can prevent and cure heart failure by inhibiting the occurrence of myocardial fibrosis. By querying relevant domestic and foreign literatures in recent years, it was found that TGF-β/Smad signaling pathway plays an important role in the development of myocardial fibrosis, it may reduce cell damage through anti-inflammatory, antioxidant stress, anti-apoptosis, etc., Maintaining extracellular matrix stability, alleviate the degree of myocardial fibrosis, Chinese medicine in the prevention and treatment of fibrosis has high efficacy, multi-target, improve long-term prognosis and other advantages. To explore a more accurate target drug for preventing and treating myocardial fibrosis in heart failure, reduce the rate of readmission of patients with heart failure, and provide a greater possibility for promoting the prevention and treatment of myocardial fibrosis in heart failure by traditional Chinese medicine.