The Role of MicroRNA in Head and Neck Cancer

Abstract

Head and neck squamous cell carcinoma (HNSCC) include epithelial tumors arising in the structures of aerodigestive tract such as oral and nasal cavity, pharynx, larynx, paranasal sinuses, and local lymph nodes. HNSCC is the sixth most common cancer worldwide, and its prognosis is very poor. MicroRNAs (miRNAs) are small single stranded noncoding RNAs which are about 19-25 nucleotides involved in cell proliferation, development, differentiation and metastasis. It is believed that miRNA alterations correlate with initiation and progression of cancer cell proliferation or inhibition of tumorigenesis especially in development, progression, and metastasis of HNSCC. Altered expression of miRNAs could be novel molecular biomarkers for the diagnosis and prognosis of HNSCC. Despite the advances in cancer treatment, the mortality rate of HNSCC is still high. The potential application of miRNAs for cancer therapy has been demonstrated in many studies. In this review, we discuss the very recent studies on different aspects of miRNA dysregulation with their clinical significance and miRNA-based therapy.