Cathepsin G degradation of phospholipid transfer protein (PLTP) augments pulmonary inflammation

Author:

Brehm Anthony1,Geraghty Patrick1,Campos Michael2,Garcia‐Arcos Itsaso34,Dabo Abdoulaye Jules1,Gaffney Adam5,Eden Edward1,Jiang Xian‐Cheng6,D'Armiento Jeanine34,Foronjy Robert1

Affiliation:

1. Division of Pulmonary and Critical Care MedicineSt. Luke's Roosevelt HospitalMt. Sinai Health SystemNew YorkNew YorkUSA

2. Division of Pulmonary and Critical Care MedicineUniversity of Miami Miller School of MedicineMiamiFloridaUSA

3. Department of MedicineColumbia UniversityNew YorkNew YorkUSA

4. Department of AnesthesiologyColumbia UniversityNew YorkNew YorkUSA

5. Department of MedicineHarvard‐Brigham and Woman's HospitalBostonMassachusettsUSA

6. Department of Anatomy and Cell BiologyState University of New York Downstate Medical CenterBrooklynNew YorkUSA

Funder

Flight Attendant Medical Research Institute

National Institutes of Health

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

Reference63 articles.

1. Complete cDNA encoding human phospholipid transfer protein from human endothelial cells;Day J. R.;J. Biol. Chem.,1994

2. Distribution of phospholipid transfer protein in human plasma: presence of two forms of phospholipid transfer protein, one catalytically active and the other inactive;Oka T.;J. Lipid. Res.,2000

3. Widespread distribution of PLTP in human CNS: evidence for PLTP synthesis by glia and neurons, and increased levels in Alzheimer's disease

4. Phospholipid transfer protein (PLTP) deficiency reduces brain vitamin E content and increases anxiety in mice.

5. Role of plasma phospholipid transfer protein in lipid and lipoprotein metabolism

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