Intravenous anesthetic propofol binds to 5‐lipoxygenase and attenuates leukotriene B 4 production

Author:

Okuno Toshiaki1,Koutsogiannaki Sophia23,Ohba Mai1,Chamberlain Matthew2,Bu Weiming4,Lin Fu‐Yan5,Eckenhoff Roderic G.4,Yokomizo Takehiko1,Yuki Koichi23

Affiliation:

1. Department of BiochemistryJuntendo University School of Medicine Tokyo Japan

2. Division of Cardiac AnesthesiaDepartment of Anesthesiology, Perioperative and Pain MedicineBoston Children's Hospital Boston Massachusetts USA

3. Department of AnesthesiaHarvard Medical School Boston Massachusetts USA

4. Department of Anesthesiology and Critical CareUniversity of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA

5. Immune Disease InstituteBoston Children's Hospital Boston Massachusetts USA

Funder

National Institutes of Health

Ministry of Education, Culture, Sports, Science and Technology

Japan Society for the Promotion of Science London

Takeda Science Foundation

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

Reference38 articles.

1. LTB4 Is a Signal-Relay Molecule during Neutrophil Chemotaxis

2. A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis

3. Leukotriene B4 receptor and the function of its helix 8;Okuno T.;J. Biol. Chem,2005

4. Leukotriene B4: Metabolism and Signal Transduction

5. Immunological quantitation and immunohistochemical localization of leukotriene A4 hydrolase in guinea pig tissues;Ohishi N.;J. Biol. Chem,1990

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