Hyperinsulinemia promotes heterologous desensitization of β2adrenergic receptor in airway smooth muscle in obesity

Author:

Xu Rui12,Gopireddy Raghavender Reddy3,Wu Yudi1,Wu Lei1,Tao Xiang1,Shao Ji1,Wang Wenxin1,Li Li12,Jovanovic Aleksandra3,Xu Bing34,Kenyon Nicolas J.5,Lu Quan6,Xiang Yang K.34,Fu Qin12

Affiliation:

1. Department of Pharmacology School of Basic Medicine Tongji Medical College Huazhong University of Science and Technology Wuhan China

2. The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province Wuhan China

3. Department of Pharmacology University of California at Davis Davis CA USA

4. VA northern California Healthcare System Mather CA USA

5. Department of Medicine University of California at Davis Davis CA USA

6. Department of Environmental Health, School of Public Health Harvard University Boston MA USA

Funder

Joint Research Fund for Overseas Chinese Scholars and Scholars in Hong Kong and Macao

National Natural Science Foundation of China

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

Reference35 articles.

1. Overweight, Obesity, and Incident Asthma

2. Body mass index and phenotype in subjects with mild‐to‐moderate persistent asthma;Sutherland ER;J Allergy Clin Immunol,2009

3. Asthma and insulin resistance in children

4. Metabolic Abnormalities in Children with Asthma

5. Insulin resistance as a predictor of incident asthma-like symptoms in adults

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