Ursolic acid facilitates apoptosis in rheumatoid arthritis synovial fibroblasts by inducing SP1‐mediated Noxa expression and proteasomal degradation of Mcl‐1-Reference-Cited by-同舟云学术

Ursolic acid facilitates apoptosis in rheumatoid arthritis synovial fibroblasts by inducing SP1‐mediated Noxa expression and proteasomal degradation of Mcl‐1

Published:2018-05-25 Issue:11 Volume:32 Page:6174-6185
ISSN:0892-6638
Container-title:The FASEB Journal
language:en
Short-container-title:FASEB j.

Author:

Kim Eugene Y.¹,Sudini Kuladeep²,Singh Anil K.¹,Haque Mahamudul¹,Leaman Douglas²,Khuder Sadik³⁴,Ahmed Salahuddin¹⁵

Affiliation:

1. Department of Pharmaceutical SciencesCollege of PharmacyWashington State UniversitySpokaneWashingtonUSA

2. Department of PharmacologyUniversity of ToledoToledoOhioUSA

3. Department of MedicineUniversity of ToledoToledoOhioUSA

4. Department of Public HealthUniversity of ToledoToledoOhioUSA

5. Division of RheumatologyUniversity of Washington School of MedicineSeattleWashingtonUSA

Funder

National Institutes of Health

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1096/fj.201800425R

Reference60 articles.

1. Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis

2. Apoptosis in rheumatoid arthritis: friend or foe

3. The Role of Synovial Fibroblasts in Mediating Joint Destruction in Rheumatoid Arthritis

4. BH3-only proteins: Orchestrators of apoptosis

5. Mcl-1 Ubiquitination: Unique Regulation of an Essential Survival Protein

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