Obesogenic diet in aging mice disrupts gut microbe composition and alters neutrophi:lymphocyte ratio, leading to inflamed milieu in acute heart failure

Author:

Kain Vasundhara1,Van Der Pol William2,Mariappan Nithya1,Ahmad Aftab3,Eipers Peter4,Gibson Deanna L.5,Gladine Cecile6,Vigor Claire7,Durand Thierry7,Morrow Casey4,Halade Ganesh V.1

Affiliation:

1. Division of Cardiovascular DiseaseDepartment of MedicineThe University of Alabama at Birmingham Birmingham Alabama USA

2. Biomedical InformaticsCenter for Clinical and Translational SciencesThe University of Alabama at Birmingham Birmingham Alabama USA

3. Department of Anesthesiology and Perioperative MedicineThe University of Alabama at Birmingham Birmingham Alabama USA

4. Department of Cell, Developmental, and Integrative BiologyThe University of Alabama at Birmingham Birmingham Alabama USA

5. Department of BiologyUniversity of British Columbia Okanagan Kelowna British Columbia Canada

6. Unité de Nutrition Humaine (UNH)Institut National de la Recherche Agronomique (INRA)Centre de Recherche en Nutrition Humaine (CRNH) AuvergneUniversité Clermont Auvergne Clermont‐Ferrand France

7. Unité Mixte de Recherche (UMR) 247Institut des Biomolécules Max Mousseron (IBMM)Centre National de la Recherche Scientifique (CNRS)Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)University of Montpellier Montpellier France

Funder

National Institutes of Health

National Center for Complementary and Integrative Health

National Center for Complementary and Alternative Medicine

University of Alabama at Birmingham

American Heart Association

Comprehensive Cancer Center, City of Hope

Center for Clinical and Translational Science, University of Illinois at Chicago

Heflin Center for Genomic Science, University of Alabama at Birmingham

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

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