Androgen receptor with elongated polyglutamine tract forms aggregates that alter axonal trafficking and mitochondrial distribution in motoneuronal processes

Author:

Piccioni Federica1,Pinton Paolo2,Simeoni Silvia3,Pozzi Paola3,Fascio Umberto4,Vismara Guglielmo3,Martini Luciano3,Rizzuto Rosario2,Poletti Angelo3

Affiliation:

1. Institute of EndocrinologyCentre of Excellence for the Study and Treatment of Neurodegenerative DiseasesUniversity of Milan Milan Italy

2. Interdisciplinary Center for the Study of Inflammation (ICSI) and Telethon Center for Cell Imaging (TCCI)Department of Experimental and Diagnostic MedicineSection of General PathologyUniversity of Ferrara Ferrara Italy

3. Centre of Excellence for the Study and Treatment of Neurodegenerative DiseasesUniversity of Milan Milan Italy

4. Department of BiologySection of Zoology and Interdepartmental Center for Advanced MicroscopyUniversity of Milan Milan Italy

Funder

Fondazione Telethon

Ministero dell’Istruzione, dell’Università e della Ricerca

Ministero della Salute

Associazione Italiana per la Ricerca sul Cancro

Center for Neuroscience Research

Human Frontier Science Program

Agenzia Spaziale Italiana

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

Reference79 articles.

1. Fourteen and counting: unraveling trinucleotide repeat diseases

2. SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein

3. Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy

4. Progressive proximal spinal and bulbar muscular atrophy of late onset;Kennedy W.R.;A sex‐linked recessive trait. Neurology,1968

5. X‐linked recessive bulbospinal neuronopathy;Sobue G.;A clinicopathological study. Brain,1989

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