Human cardiac myosin autoantibodies impair myocyte contractility: a cause‐and‐effect relationship

Author:

Warraich Rahat S.1,Griffiths Elinor2,Falconar Andrew3,Pabbathi Vijay2,Bell Chris2,Angelini Gianni2,Suleiman M.‐Saadeh2,Yacoub Magdi H.1

Affiliation:

1. Department of Cardiothoracic SurgeryNational Heart and Lung InstituteImperial College School of MedicineRoyal Brompton and Harefield TrustHarefield HospitalMiddlesex UK

2. Bristol Heart InstituteUniversity of BristolBristol Royal Infirmary Bristol England UK

3. London School of Hygiene and Tropical MedicineLondon UK

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

Reference29 articles.

1. Circulating heart-reactive antibodies in patients with myocarditis or cardiomyopathy

2. Autoantibodies against beta-adrenoceptors in human idiopathic dilated cardiomyopathy.

3. The antigenic characteristics and the significance of the adenine nucleotide translocator (ANT) as a major autoantigen for antimitochondrial antibodies in dilated cardiomyopathy;Schultheiss H. P.;Adv. Myocardial,1985

4. Epitope mapping of the branched chain alpha chain ketoacid dehydrogenase dihydrolipoyl transacylase (BCKD‐E2) protein that reacts with sera from patients with idiopathic dilated cardiomyopathy;Ansari A. A.;J. Immunol.,1994

5. Identification of alpha- and beta-cardiac myosin heavy chain isoforms as major autoantigens in dilated cardiomyopathy.

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