Short DNA sequences inserted for gene targeting can accidentally interfere with off‐target gene expression
Author:
Affiliation:
1. Center for Molecular Neurobiology University Medical Center Hamburg‐Eppendorf Hamburg Germany
2. Institute for Clinical Chemistry University Medical Center Hamburg‐Eppendorf Hamburg Germany
Funder
Alexander von Humboldt-Stiftung
Publisher
Wiley
Subject
Genetics,Molecular Biology,Biochemistry,Biotechnology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1096/fj.09-140749
Reference40 articles.
1. An “in‐out” strategy using gene targeting and FLP recombinase for the functional dissection of complex DNA regulatory elements: analysis of the beta‐globin locus control region;Fiering S.;Proc. Natl. Acad. Sci. U. S. A.,1993
2. Inactivation of the human beta‐globin gene by targeted insertion into the beta‐globin locus control region;Kim C. G.;Genes Dev.,1992
3. Know your neighbors: three phenotypes in null mutants of the myogenic bHLH gene MRF4;Olson E. N.;Cell,1996
4. Long‐range disruption of gene expression by a selectable marker cassette;Pham C. T.;Proc. Natl. Acad. Sci. U. S. A.,1996
5. Insertion of a targeting construct in a Hoxd‐10 allele can influence the control of Hoxd‐9 expression;Rijli F. M.;Dev. Dyn.,1994
Cited by 72 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Concerns regarding the interpretation of Shank3 protein isoforms expressed in Shank3B-/- mice: potential off-target effects by a neomycin resistance cassette;Molecular Psychiatry;2024-08-27
2. Evaluating possible maternal effect lethality and genetic background effects in Naa10 knockout mice;PLOS ONE;2024-05-07
3. Detailed phenotyping ofTbr1-2A-CreERknock-in mice demonstrates significant impacts on TBR1 protein levels and axon development;2024-04-04
4. Insertion of a neomycin selection cassette in the Amigo1 locus alters gene expression in the olfactory epithelium leading to region‐specific defects in olfactory receptor neuron development;genesis;2024-04
5. Generation and validation of a myoglobin knockout zebrafish model;Transgenic Research;2023-10-17
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3