Calpain inhibitor MDL28170 modulates Aβ formation by inhibiting the formation of intermediate Aβ46and protecting Aβ from degradation
Author:
Affiliation:
1. Department of Pathobiology, College of Veterinary MedicineThe University of Tennessee 37996 Knoxville Tennessee
2. Department of PathologyCase Western Reserve University 44106 Cleveland Ohio
Funder
National Institutes of Health
American Heart Association
Publisher
Wiley
Subject
Genetics,Molecular Biology,Biochemistry,Biotechnology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1096/fj.05-4524fje
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1. Alzheimer's Disease: Genes, Proteins, and Therapy
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3. The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease
4. Calpain inhibitor I decreases βA4 secretion from human embryonal kidney cells expressing β-amyloid precursor protein carrying the APP670/671 double mutation
5. Inhibition of β-amyloid formation identifies proteolytic precursors and subcellular site of catabolism
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