Peptides based on the presenilin‐APP binding domain inhibit APP processing and Aβ production through interfering with the APP transmembrane domain-Reference-Cited by-同舟云学术

Peptides based on the presenilin‐APP binding domain inhibit APP processing and Aβ production through interfering with the APP transmembrane domain

Published:2012-06 Issue:9 Volume:26 Page:3765-3778
ISSN:0892-6638
Container-title:The FASEB Journal
language:en
Short-container-title:FASEB j.

Author:

Esselens Cary¹²,Sannerud Ragna¹²,Gallardo Rodrigo³⁴,Baert Veerle¹²,Kaden Daniela⁵,Serneels Lutgarde⁶²,De Strooper Bart⁶²,Rousseau Frederic³⁴,Multhaup Gerd⁵⁷,Schymkowitz Joost³⁴,Langedijk Johannes P. M.⁸,Annaert Wim¹²

Affiliation:

1. Laboratory for Membrane TraffickingLeuvenBelgium

2. Vlaams Instituut voor Biotechnologie (VIB) Center for the Biology of DiseaseLeuvenBelgium

3. Department of Molecular MedicineKatholieke Universiteit LeuvenLeuvenBelgium

4. VIB Switch LaboratoryGasthuisbergLeuvenBelgium

5. Institut für Chemie und BiochemieFreie UniversitätBerlinGermany

6. Laboratory for the Research of Neurodegenerative DiseasesCenter for Human GeneticsLeuvenBelgium

7. Department of Pharmacology and TherapeuticsMcGill UniversityMontrealQuebecCanada

8. Pepscan TherapeuticsLelystadThe Netherlands

Funder

KU Leuven

Internationale Stichting Alzheimer Onderzoek

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1096/fj.11-201368

Reference68 articles.

1. Interaction with Telencephalin and the Amyloid Precursor Protein Predicts a Ring Structure for Presenilins

3. Estimation of the Genetic Contribution of Presenilin-1 and -2 Mutations in a Population-Based Study of Presenile Alzheimer Disease

4. Novel Research Horizons for Presenilins and γ-Secretases in Cell Biology and Disease

5. γ-secretases: from cell biology to therapeutic strategies

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