Fibroblast growth factor represses Smad‐mediated myofibroblast activation in aortic valvular interstitial cells

Author:

Cushing Melinda C.1,Mariner Peter D.12,Liao Jo‐Tsu1,Sims Evan A.1,Anseth Kristi S.12

Affiliation:

1. Department of Chemical and Biological EngineeringUniversity of ColoradoBoulderColoradoUSA

2. Howard Hughes Medical InstituteUniversity of ColoradoBoulderColoradoUSA

Funder

Howard Hughes Medical Institute

American Heart Association

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

Reference40 articles.

1. Valvular Myofibroblast Activation by Transforming Growth Factor-β

2. Tumor necrosis factor alpha promotes an osteoblast‐like phenotype in human aortic valve myofibroblasts: a potential regulatory mechanism of valvular calcification;Kaden J. J.;Int. J. Mol. Med.,2005

3. Progression of aortic valve stenosis: TGF-β1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis

4. Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar;Desmouliere A.;Am. J. Pathol.,1995

5. Dynamic and reversible changes of interstitial cell phenotype during remodeling of cardiac valves;Rabkin‐Aikawa E.;J. Heart Valve Dis.,2004

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