Cytotoxicity of sulfonamide reactive metabolites: apoptosis and selective toxicity of CD8 + cells by the hydroxylamine of sulfamethoxazole-Reference-Cited by-同舟云学术

Cytotoxicity of sulfonamide reactive metabolites: apoptosis and selective toxicity of CD8 + cells by the hydroxylamine of sulfamethoxazole

Published:1999-10 Issue:13 Volume:13 Page:1688-1698
ISSN:0892-6638
Container-title:The FASEB Journal
language:en
Short-container-title:FASEB j.

Author:

Hess David A.¹,Sisson Margaret E.,Suria Hamza²,Wijsman John,Puvanesasingham Ram,Madrenas Joaquín²,Rieder Michael J.³

Affiliation:

1. Department of Pharmacology and ToxicologyUniversity of Western Ontario London Ontario Canada

2. Departments of Medicine, Microbiology and ImmunologyUniversity of Western OntarioTransplantation and Immunobiology GroupJohn P. Robarts Research Institute London Ontario Canada

3. Departments of Pediatrics, Pharmacology and ToxicologyChildren's Hospital of Western OntarioUniversity of Western OntarioGene Therapy and Molecular Virology GroupJohn P. Robarts Research Institute London Ontario Canada

Funder

Medical Research Council

National Health Research Institutes

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1096/fasebj.13.13.1688

Reference73 articles.

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2. Adverse reactions to trimethoprim-sulfamethoxazole among children with human immunodeficiency virus infection

3. Sulfamethoxazole is metabolized to the hydroxylamine in humans

4. N4‐hydroxylation of sulfamethoxazole by cytochrome P450 of the cytochrome P4502C subfamily and reduction of sulfamethoxazole hydroxylamine in human and rat hepatic microsomes;Cribb A. E.;Drug Metab. Disp.,1995

5. Hepatic microsomal metabolism of sulfa‐methoxazole to the hydroxylamine;Cribb A. E.;Drug Metab. Dispos.,1990

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