Expression of the human α:1,2‐fucosyltransferase in transgenic pigs modifies the cell surface carbohydrate phenotype and confers resistance to human serum‐mediated cytolysis

Author:

Costa Cristina1,Zhao Lisa1,Burton Willis V.1,Bondioli Kenneth R1,Williams Barry L.2,Hoagland Thomas A.3,Ditullio Paul A.4,Ebert Karl M.4,Fodor William L.1

Affiliation:

1. Department of Molecular Sciences Alexion Pharmaceuticals Inc New Haven Connecticut 06511 USA

2. U.S. Surgical Corporation North Haven Connecticut 06473 USA

3. Department of Animal Sciences University of Connecticut Storrs Connecticut 06269 USA

4. TranXenoGen Shrewsbury Massachusetts 01545 USA

Funder

National Institute of Standards and Technology

Telemedicine and Advanced Technology Research Center

Oktatási és Kulturális Minisztérium

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

Reference57 articles.

1. XENOGENEIC TRANSPLANTATION

2. Discordant xenografting: challenges and controversies

3. Future directions in transplantation: xenotransplantation;Sommerville C. A.;Kidney Int.,1993

4. Mechanism of complement activation in the hyperacute rejection of porcine organs in primate recipients;Dalmasso A. P.;Am. J. Pathol.,1992

5. Xenotransplantation

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