The secondary alcohol metabolite of doxorubicin irreversibly inactivates aconitase/iron regulatory protein‐1 in cytosolic fractions from human myocardium

Author:

Minotti Giorgio1,Recalcati Stefania2,Mordente Alvaro3,Liberi Giovanni4,Calafiore Antonio Maria4,Mancuso Cesare1,Preziosi Paolo1,Cairo Gaetano5

Affiliation:

1. Department of PharmacologyCatholic University School of MedicineRomeItaly

2. Department of GastroenterologyUniversity of Milan School of Medicine‐IRCCS Ospedale MaggioreItaly

3. Department of BiochemistryCatholic University School of MedicineRomeItaly

4. Department of Cardiac SurgeryG. D'Annunzio University School of MedicineChietiItaly

5. CNR Center for Cell PathologyMilanItaly

Funder

Consiglio Nazionale delle Ricerche

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

Reference49 articles.

1. The anthracyclines: will we ever find a better doxorubicin?;Weiss R. B.;Sem. Oncol.,1992

2. Cytoprotective agents for anthracyclines;Dorr R. T.;Sem. Oncol.,1996

3. Doxorubicin cardiotoxicity: analysis of prevailing hypotheses

4. Free radical formation by antitumor quinones

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