LncRNASnhg3 regulates mouse hepatic glycogenesis under normal chow diet

Author:

Xie Xianghong1ORCID,Gao Mingyue1ORCID,Wang Heping1ORCID,Zhang Minglong2ORCID,Zhao Wei1ORCID,Li Chunmei1ORCID,Zhang Weihong3ORCID,Yang Jiahui3ORCID,Zhang Yinliang1ORCID,Chen Enhui2ORCID,Guo Yanfang1ORCID,Guo Zeyu1ORCID,Ngowi Ebenezeri Erasto45ORCID,Wang Xiaoman1ORCID,Zhu Yinghan2ORCID,Wang Yiting1ORCID,Li Xiaolu1ORCID,Yao Hong3ORCID,Yan Li2ORCID,Fang Fude1ORCID,Li Meixia6ORCID,Qiao Aijun45ORCID,Liu Xiaojun1ORCID

Affiliation:

1. State Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry & Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences & School of Basic Medicine Peking Union Medical College Beijing China

2. Department of Pathophysiology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences & School of Basic Medicine Peking Union Medical College Beijing China

3. Department of Microbiology and Immunology Shanxi Medical University Taiyuan China

4. Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China

5. Zhongshan Institute for Drug Discovery Shanghai Institute of Materia Medica, Chinese Academy of Sciences Zhongshan Guangdong China

6. State Key Laboratory of Brain and Cognitive Science Institute of Biophysics, Chinese Academy of Sciences Beijing China

Abstract

AbstractLong noncoding RNAs (lncRNAs) are strongly associated with glucose homeostasis, but their roles remain largely unknown. In this study, the potential role of lncRNA‐Snhg3 in glucose metabolism was evaluated both in vitro and in vivo. Here, we found a positive relationship between Snhg3 and hepatic glycogenesis. Glucose tolerance improved in hepatocyte‐specific Snhg3 knock‐in (Snhg3‐HKI) mice, while it worsened in hepatocyte‐specific Snhg3 knockout (Snhg3‐HKO) mice. Furthermore, hepatic glycogenesis had shown remarkable increase in Snhg3‐HKI mice and reduction in Snhg3‐HKO mice, respectively. Mechanistically, Snhg3 increased mRNA and protein expression levels of PPP1R3B through inducing chromatin remodeling and promoting the phosphorylation of protein kinase B. Collectively, these results suggested that lncRNA‐Snhg3 plays a critical role in hepatic glycogenesis.

Funder

National Key Research and Development Program of China

Natural Science Foundation of Beijing Municipality

National Natural Science Foundation of China

Publisher

Wiley

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3