Affiliation:
1. Shanghai Institute of Materia Medica (SIMM) Chinese Academy of Sciences Shanghai China
2. University of Chinese Academy of Sciences Beijing China
3. Laboratory of Cellular Immunity, Shanghai Key Laboratory of Traditional Chinese Medicine Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai China
Abstract
AbstractMetabolic dysfunction‐associated diseases often refer to various diseases caused by metabolic problems such as glucose and lipid metabolism disorders. With the improvement of living standards, the increasing prevalence of metabolic diseases has become a severe public health problem, including metabolic dysfunction‐associated steatotic liver disease (MASLD), alcohol‐related liver disease (ALD), diabetes and obesity. These diseases are both independent and interdependent, with complex and diverse molecular mechanisms. Therefore, it is urgent to explore the molecular mechanisms and find effective therapeutic targets of these diseases. MicroRNAs (miRNAs) have emerged as key regulators of metabolic homoeostasis due to their multitargets and network regulatory properties within the past few decades. In this review, we discussed the latest progress in the roles of miRNA‐mediated regulatory networks in the development and progression of MASLD, ALD, diabetes and obesity.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Shanghai Municipality