Transcriptomic and epigenetic regulation of disuse atrophy and the return to activity in skeletal muscle

Author:

Fisher Andrew G.1,Seaborne Robert A.23,Hughes Thomas M.4,Gutteridge Alex5,Stewart Claire2,Coulson Judy M.6,Sharples Adam P.23,Jarvis Jonathan C.3

Affiliation:

1. Institute for Ageing and Chronic DiseaseUniversity of Liverpool Liverpool United Kingdom

2. Institute for Science and Technology in MedicineKeele University Medical SchoolKeele University Staffordshire United Kingdom

3. Stem Cells, Ageing, and Molecular Physiology Research UnitExercise Metabolism and Adaptation Research GroupResearch Institute for Sport and Exercise SciencesLiverpool John Moores University Liverpool United Kingdom

4. Instituto de Física y AstronomíaUniversidad de Valparaíso Valparaíso Chile

5. Pfizer Tadworth United Kingdom

6. Department of Cellular and Molecular PhysiologyInstitute of Translational MedicineUniversity of Liverpool Liverpool United Kingdom

Funder

Medical Research Council

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

Reference55 articles.

1. Prolonged bed rest decreases skeletal muscle and whole body protein synthesis;Ferrando A. A.;Am. J. Physiol.,1996

2. Regional changes in muscle mass following 17 weeks of bed rest;LeBlanc A.D.;J. Appl. Physiol. (1985),1992

3. Decrease in human quadriceps muscle protein turnover consequent upon leg immobilization;Gibson J. N.;Clin. Sci. (Lond.),1987

4. The effect of immobilization on metabolic and physiological functions of normal men;Deitrick J. E.;Bull. N. Y. Acad. Med.,1948

5. Cancer cachexia is regulated by selective targeting of skeletal muscle gene products;Acharyya S.;J. Clin. Invest.,2004

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