Sildenafil in hypoxic pulmonary hypertension potentiates a compensatory up‐regulation of NO‐cGMP signaling

Author:

Kirsch Mark1,Kemp‐Harper Barbara2,Weissmann Norbert3,Grimminger Friedrich3,Schmidt Harald H. H. W.2

Affiliation:

1. Rudolf‐Buchheim‐Institute of PharmacologyJustus‐Liebig‐University GiessenGermany

2. Department of Pharmacology and Centre for Vascular HealthMonash UniversityMelbourneAustralia

3. University of Giessen Lung CenterMedical Clinic II/VGiessenGermany

Funder

Deutsche Forschungsgemeinschaft

National Health and Medical Research Council

National Heart Foundation of Australia

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

Reference72 articles.

1. Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical.

2. Pharmacological evidence that endothelium‐derived relaxing factor is nitric oxide: use of pyrogallol and superoxide dismutase to study endothelium‐dependent and nitric oxide‐elicited vascular smooth muscle relaxation;Ignarro L. J.;J. Pharmacol. Exp. Ther.,1988

3. Functional Reconstitution of Vascular Smooth Muscle Cells With cGMP-Dependent Protein Kinase I Isoforms

4. Loss of endothelium‐dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia;Adnot S.;J. Clin. Invest.,1990

5. Effects of hypoxia on endothelium‐dependent relaxation of rat pulmonary artery;Rodman D. M.;Am. J. Physiol.,1990

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