Sildenafil in hypoxic pulmonary hypertension potentiates a compensatory up‐regulation of NO‐cGMP signaling
Author:
Affiliation:
1. Rudolf‐Buchheim‐Institute of PharmacologyJustus‐Liebig‐University GiessenGermany
2. Department of Pharmacology and Centre for Vascular HealthMonash UniversityMelbourneAustralia
3. University of Giessen Lung CenterMedical Clinic II/VGiessenGermany
Funder
Deutsche Forschungsgemeinschaft
National Health and Medical Research Council
National Heart Foundation of Australia
Publisher
Wiley
Subject
Genetics,Molecular Biology,Biochemistry,Biotechnology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1096/fj.06-7526com
Reference72 articles.
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2. Pharmacological evidence that endothelium‐derived relaxing factor is nitric oxide: use of pyrogallol and superoxide dismutase to study endothelium‐dependent and nitric oxide‐elicited vascular smooth muscle relaxation;Ignarro L. J.;J. Pharmacol. Exp. Ther.,1988
3. Functional Reconstitution of Vascular Smooth Muscle Cells With cGMP-Dependent Protein Kinase I Isoforms
4. Loss of endothelium‐dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia;Adnot S.;J. Clin. Invest.,1990
5. Effects of hypoxia on endothelium‐dependent relaxation of rat pulmonary artery;Rodman D. M.;Am. J. Physiol.,1990
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