β‐Secretase inhibitor GRL‐8234 rescues age‐related cognitive decline in APP transgenic mice-Reference-Cited by-同舟云学术

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β‐Secretase inhibitor GRL‐8234 rescues age‐related cognitive decline in APP transgenic mice

Published:2010-11-08 Issue:2 Volume:25 Page:775-784
ISSN:0892-6638
Container-title:The FASEB Journal
language:en
Short-container-title:FASEB j.

Author:

Chang Wan‐Pin¹,Huang Xiangping¹,Downs Deborah¹,Cirrito John R.²,Koelsch Gerald³,Holtzman David M.²,Ghosh Arun K.⁴,Tang Jordan¹⁵

Affiliation:

1. Protein Studies ProgramOklahoma Medical Research FoundationUniversity of Oklahoma Health Science CenterOklahoma CityOklahomaUSA

2. Department of NeurologyMicrodialysis Core FacilityWashington University School of MedicineSt. LouisMissouriUSA

3. CoMentis, Inc.Oklahoma CityOklahomaUSA

4. Department of ChemistryPurdue UniversityWest LafayetteIndianaUSA

5. Department of Biochemistry and Molecular BiologyUniversity of Oklahoma Health Science CenterOklahoma CityOklahomaUSA

Funder

National Institutes of Health

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1096/fj.10-167213

Reference36 articles.

1. Alzheimer's Disease: Molecular Understanding Predicts Amyloid-Based Therapeutics

2. Human aspartic protease memapsin 2 cleaves the beta -secretase site of beta -amyloid precursor protein

3. Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity

4. β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

5. Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

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1. What Threshold of Amyloid Reduction Is Necessary to Meaningfully Improve Cognitive Function in Transgenic Alzheimer’s Disease Mice?;Journal of Alzheimer's Disease Reports;2024-02-29

2. Combination strategy employing BACE1 inhibitor and memantine to boost cognitive benefits in Alzheimer’s disease therapy;Psychopharmacology;2024-01-10

3. Transgenic amyloid precursor protein mouse models of amyloidosis. Incomplete models for Alzheimer's disease but effective predictors of anti‐amyloid therapies;Alzheimer's & Dementia;2023-12-12

4. Accelerated long-term forgetting: A sensitive paradigm for detecting subtle cognitive impairment and evaluating BACE1 inhibitor efficacy in preclinical Alzheimer's disease;Frontiers in Dementia;2023-04-18

5. Small-molecule drugs development for Alzheimer's disease;Frontiers in Aging Neuroscience;2022-11-01

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