Affiliation:
1. The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology Qilu Hospital, Cheeloo College of Medicine, Shandong University Jinan China
2. Cardiovascular Disease Research Center of Shandong First Medical University Central Hospital Affiliated to Shandong First Medical University Jinan China
Abstract
AbstractTechnology at the single‐cell level has advanced dramatically in characterizing molecular heterogeneity. These technologies have enabled cell subtype diversity to be seen in all tissues, including atherosclerotic plaques. Critical in atherosclerosis pathogenesis and progression are macrophages. Previous studies have only determined macrophage phenotypes within the plaque, mainly by bulk analysis. However, recent progress in single‐cell technologies now enables the comprehensive mapping of macrophage subsets and phenotypes present in plaques. In this review, we have updated and discussed the definition and classification of macrophage subsets in mice and humans using single‐cell RNA sequencing. We summarized the different classification methods and perspectives: traditional classification with an updated scoring system, inflammatory macrophages, foamy macrophages, and atherosclerotic‐resident macrophages. In addition, some special types of macrophages were identified by specific markers, including IFN‐inducible and cavity macrophages. Furthermore, we discussed macrophage subset‐specific markers and their functions. In the future, these novel insights into the characteristics and phenotypes of these macrophage subsets within atherosclerotic plaques can provide additional therapeutic targets for cardiovascular diseases.
Funder
Shandong Provincial Postdoctoral Science Foundation
China Postdoctoral Science Foundation
Major Scientific and Technological Innovation Project of Shandong Province
National Key Research and Development Program of China
National Natural Science Foundation of China
Natural Science Foundation of Shandong Province
Taishan Scholar Project of Shandong Province
Subject
Genetics,Molecular Biology,Biochemistry,Biotechnology
Cited by
11 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献