Affiliation:
1. Department of Cell and Regenerative Biology University of Wisconsin‐Madison Madison Wisconsin USA
Abstract
AbstractThe axon guidance proteins, Roundabout (Robo) receptors play a critical role in morphogenesis of the islets of Langerhans. Mice with a β cell‐selective deletion of Robo (Robo βKO), show severely disrupted spatial architecture of their islets, without defects in β cell differentiation or maturity. We have recently shown that Robo βKO mice have reduced synchronous glucose‐stimulated β cell calcium oscillations in their islets in vivo, likely disrupting their pulsatile insulin secretion. Here, we analyze whole‐body metabolic regulation in Robo βKO mice. We show that Robo βKO mice have mild defects in glucose homeostasis, and altered glucagon and insulin secretion. However, we did not observe any severe whole‐body glucoregulatory phenotype following the disruption of islet architecture in Robo βKO. Our data suggest that islet architecture plays only a mild role in overall glucoregulation.
Funder
National Institute of Diabetes and Digestive and Kidney Diseases
National Institute of General Medical Sciences
Subject
Genetics,Molecular Biology,Biochemistry,Biotechnology
Cited by
2 articles.
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