Acetaminophen,viaits reactive metabolite N‐acetyl‐p‐benzo‐quinoneimine and transient receptor potential ankyrin‐1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents

Author:

Nassini Romina1,Materazzi Serena1,Andrè Eunice1,Sartiani Laura12,Aldini Giancarlo3,Trevisani Marcello4,Camini Chiara5,Massi Daniela6,Pedretti Pamela5,Carini Marina7,Cerbai Elisabetta8,Preti Delia9,Villetti Gino1,Civelli Maurizio8,Trevisan Gabriela5,Azzari Chiara1,Stokesberry Susan1,Sadofsky Laura1,McGarvey Lorcan1,Patacchini Riccardo1,Geppetti Pierangelo1

Affiliation:

1. Department of Preclinical and Clinical PharmacologyUniversity of Florence Florence Italy

2. Division of Cardiovascular and Respiratory StudiesUniversity of Hull, Castle Hill Hospital Hull UK

3. Department of Pharmaceutical SciencesUniversity of Milan Milan Italy

4. Pharmeste Srl Ferrara Italy

5. Pharmacology DepartmentChiesi Farmaceutici SpA Parma Italy

6. Department of Human Pathology and OncologyUniversity of Florence Florence Italy

7. Department of PediatricsUniversity of Florence Florence Italy

8. Department of Pharmaceutical ChemistryUniversity of Ferrara Ferrara Italy

9. Centre for Infection and ImmunityQueen's University Belfast Belfast UK

Funder

Ministero dell’Istruzione, dell’Università e della Ricerca

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

Reference50 articles.

1. National patterns of aspirin use and Reye syndrome reporting, United States, 1980 to 1985;Arrowsmith J. B.;Pediatrics,1987

2. N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen.

3. Paracetamol use in pregnancy and wheezing in early childhood

4. Factors associated with allergic rhinitis in children from northern Mexico City;Del‐Rio‐Navarro B. E.;J. Investig. Allergol. Clin. Immunol.,2007

5. Frequent paracetamol use and asthma in adults

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